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Related Experiment Videos

Glucose uptake in dilated small intestine

A L Kawaguchi1, J C Dunn, M Lam

  • 1Division of Pediatric Surgery, UCLA School of Medicine, Los Angeles, California 90095, USA.

Journal of Pediatric Surgery
|December 18, 1998
PubMed
Summary

Dilated small intestine in short bowel syndrome increases surface area but decreases absorptive function per unit area. Overall glucose absorption slightly increases, suggesting dilation may not improve mucosal absorption.

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Area of Science:

  • Gastroenterology
  • Physiology
  • Surgical Research

Background:

  • Short bowel syndrome (SBS) leads to small intestine dilation, increasing mucosal surface area.
  • The relationship between increased surface area and absorptive function in dilated small intestine is not fully understood.

Purpose of the Study:

  • To investigate if increased mucosal surface area in a dilated small intestine proportionally enhances absorptive function.
  • To determine the effect of dilation on glucose uptake in the small intestine.

Main Methods:

  • Partial small intestine obstruction was surgically created in rats using an intussusception valve.
  • Intestinal diameter and glucose uptake (using the everted sleeve technique) were measured in dilated and control segments.
  • Data were analyzed using analysis of variance (ANOVA).

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Main Results:

  • The intestine proximal to the obstruction showed significant dilation and thickening compared to controls.
  • Wet mass per centimeter of the dilated segment was 2.5 times greater than controls (P<.001).
  • While overall glucose uptake capacity slightly increased (P<.05), the specific glucose uptake rate per unit area significantly decreased (P<.01).

Conclusions:

  • Partial small intestine obstruction increased intestinal surface area but reduced absorptive capacity per unit area.
  • The overall functional absorptive capacity for glucose showed only a slight increase.
  • These findings suggest that small intestine dilation may not enhance mucosal absorption in SBS.