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In vitro sensitivity of enteric bacteria to epicillin, chloramphenicol, ampicillin and furazolidone
Abstract:
Strains of Salmonella typhi (148) and Salmonella paratyphi A (27) isolated from the blood of patients with clinical features of enteric fever were tested in vitro for their sensitivity to epicillin, ampicillin, chloramphenicol and furazolidone. Results from both the disc and tube dilution methods showed that greater percentages of the two strains were sensitive to epicillin than to the other antibiotics.
Insights
Epicillin demonstrated higher in vitro sensitivity against Salmonella typhi and Salmonella paratyphi A compared to ampicillin, chloramphenicol, and furazolidone in enteric fever patients. This finding suggests epicillin may be a valuable therapeutic option for treating these infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Enteric fever, caused by Salmonella species, remains a significant global health concern.
- Antimicrobial resistance is a growing challenge in treating Salmonella infections.
- Salmonella typhi and Salmonella paratyphi A are the primary causative agents of enteric fever.
Purpose of the Study:
- To evaluate the in vitro antimicrobial sensitivity of clinical isolates of Salmonella typhi and Salmonella paratyphi A.
- To compare the efficacy of epicillin against commonly used antibiotics for enteric fever.
Main Methods:
- Clinical isolates of Salmonella typhi (n=148) and Salmonella paratyphi A (n=27) were obtained from patients with enteric fever.
- In vitro antimicrobial sensitivity testing was performed using both disc diffusion and tube dilution methods.
- Antibiotics tested included epicillin, ampicillin, chloramphenicol, and furazolidone.
Main Results:
- Higher percentages of both Salmonella typhi and Salmonella paratyphi A strains exhibited sensitivity to epicillin compared to other tested antibiotics.
- Sensitivity patterns varied among the different antibiotics evaluated.
- Epicillin showed promising in vitro activity against the studied Salmonella isolates.
Conclusions:
- Epicillin appears to be a potentially effective antibiotic for treating infections caused by Salmonella typhi and Salmonella paratyphi A.
- Further clinical studies are warranted to confirm the therapeutic utility of epicillin in patients with enteric fever.
- Monitoring antimicrobial susceptibility is crucial for guiding effective treatment strategies against enteric fever pathogens.