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[Pathophysiologic programming of cell death]

W Dobryszycka1

  • 1Katedra Biochemii Farmaceutycznej Akademii Medycznej, Wrocławiu.

Postepy Higieny I Medycyny Doswiadczalnej
|December 19, 1998
PubMed
Summary
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Programmed cell death, or apoptosis, is vital for maintaining health in multicellular organisms. Dysregulation of apoptosis contributes to diseases like cancer and AIDS, offering therapeutic targets.

Area of Science:

  • Cell Biology
  • Physiology
  • Biochemistry

Context:

  • Homeostasis in multicellular organisms relies on the balance between cell proliferation and cell death.
  • Programmed cell death (apoptosis) is a fundamental physiological process.
  • Understanding apoptosis is crucial for comprehending various disease pathologies.

Purpose:

  • To review the fundamental principles of programmed cell death (apoptosis).
  • To describe the biochemical features, involved genes, and proteolytic enzymes of apoptosis.
  • To discuss methods for the quantitative determination of apoptosis.

Summary:

  • This review details the physiology of apoptosis, including its biochemical mechanisms, genetic regulation, and enzymatic components.
  • It highlights the role of apoptosis alterations in the pathogenesis of diseases such as cancer, viral infections, inflammation, immune disorders (e.g., AIDS), and neurodegenerative conditions.

Related Experiment Videos

  • The discussion includes methods for quantifying apoptosis and explores its potential as a therapeutic target.

    • Impact:

    • Altered apoptosis is implicated in numerous human diseases, underscoring its pathological significance.
    • Targeting apoptosis regulation presents novel therapeutic strategies for various human ailments.
    • Quantitative methods for apoptosis assessment are essential for research and clinical applications.