Related Experiment Video
Updated: Aug 24, 2026

Creation of Reversible Cholestatic Rat Model
Published on: May 21, 2011
[Cholestasis: interventional therapy]
1Medizinische Klinik II, Dr.-Horst-Schmidt-Kliniken, Wiesbaden.
Abstract:
Treatment of cholestasis by bile duct obstruction is nowadays dominated by endoscopy and other interventional measures. Intraductal concrements can be removed almost always without open surgery. This is as a rule achieved by a transpapillary approach with the additional use of lithothripsy. Percutaneous transhepatic treatment of concrements is restricted to patients in which a transpapillary approach is impossible. Stenoses of biliary ducts by malignancies are treated with plastic or metallic endoprosthesis if curative resection is precluded. Percutaneous drainage is a valid option in reserve. Stenosis of the papilla by scars, tumors or sphincter dysfunction are mainly treated endoscopically, malignancies--if possible--by radical surgery. Rare causes for obstruction have also to be considered. They are in most instances amenable to interventional procedures.
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