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Related Experiment Videos

Epileptic periodic alternating nystagmus

M L Moster1, E Schnayder

  • 1Department of Neurosensory Sciences, Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141, USA.

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
|December 19, 1998
PubMed
Summary

Seizures can cause periodic alternating nystagmus (PAN), gaze deviation, and head rotation, especially after hypoxic ischemic encephalopathy. Clinicians should consider seizures in PAN differential diagnoses.

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Area of Science:

  • Neurology
  • Ophthalmology
  • Neurophysiology

Background:

  • Periodic alternating nystagmus (PAN) is a rare, involuntary eye movement disorder.
  • Hypoxic ischemic encephalopathy (HIE) can lead to various neurological sequelae.
  • The etiology of PAN is often idiopathic or associated with specific neurological conditions.

Observation:

  • A patient recovering from hypoxic ischemic encephalopathy (HIE) exhibited new-onset periodic alternating nystagmus (PAN).
  • The patient also displayed periodic alternating gaze deviation and periodic alternating head rotation.
  • These abnormal movements coincided with seizure activity during the patient's awakening phase.

Findings:

  • Seizure activity was identified as the direct cause of the observed periodic alternating nystagmus (PAN), gaze deviation, and head rotation.

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  • The clinical presentation suggests a specific ictal manifestation involving these periodic alternating movements.
  • This case highlights an unusual presentation of seizures in the context of HIE recovery.

    • Implications:

    • Seizures should be recognized as a potential cause of periodic alternating nystagmus (PAN).
    • Expanding the differential diagnosis for PAN to include seizures may improve diagnostic accuracy.
    • This finding could prompt further research into the neurophysiological mechanisms linking seizures and PAN.