Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromosomal abnormalities in systemic amyloidosis

R Fonseca1, G J Ahmann, S M Jalal

  • 1Division of Hematology and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.

British Journal of Haematology
|December 19, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Outcomes among newly diagnosed AL amyloidosis patients with a very high NT-proBNP: implications for trial design.

Leukemia·2024
Same author

Daratumumab, carfilzomib, and pomalidomide for the treatment of POEMS syndrome: The Mayo Clinic Experience.

Blood cancer journal·2023
Same author

"Real-life" data of the efficacy and safety of belantamab mafodotin in relapsed multiple myeloma-the Mayo Clinic experience.

Blood cancer journal·2021
Same author

Outcomes among newly diagnosed AL amyloidosis patients with a very high NT-proBNP: implications for trial design.

Leukemia·2021
Same author

Systemic amyloidosis from A (AA) to T (ATTR): a review.

Journal of internal medicine·2020
Same author

N-glycosylation of monoclonal light chains on routine MASS-FIX testing is a risk factor for MGUS progression.

Leukemia·2020
Same journal

Author response to Zhang and Chen.

British journal of haematology·2026
Same journal

Response-adapted chimeric antigen receptor T cell (CAR-T)-sparing consolidation radiotherapy in high-risk large B-cell lymphoma (LBCL): Results of the prospective RESTART protocol.

British journal of haematology·2026
Same journal

Prospective, multicentre phase II study to evaluate the clinical benefit of reduced-dose lenalidomide and dexamethasone based on frailty stratification in elderly, unfit patients with newly diagnosed multiple myeloma.

British journal of haematology·2026
Same journal

Real-world effectiveness and safety of acalabrutinib in chronic lymphocytic leukaemia: Multicentre experience.

British journal of haematology·2026
Same journal

Novel germline GATA1s-generating variant associates with somatic STAG2 variants in hypoplastic myelodysplastic neoplasm.

British journal of haematology·2026
Same journal

The Endothelial Activation and Stress Index (EASIX) at diagnosis is associated with survival in primary central nervous system lymphoma.

British journal of haematology·2026
See all related articles

Systemic amyloidosis (AL) involves abnormal plasma cells. Interphase FISH revealed multiple numerical chromosomal abnormalities in AL patients, particularly chromosome 18 monosomy, supporting its neoplastic nature.

Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • Primary systemic amyloidosis (AL) is a plasma cell disorder with light chain deposition.
  • Chromosomal abnormalities are known in multiple myeloma but uncharacterized in AL.

Purpose of the Study:

  • To investigate numerical chromosomal abnormalities in AL using interphase FISH.
  • To compare AL findings with monoclonal gammopathy of undetermined significance (MGUS) and normal controls.

Main Methods:

  • Bone marrow samples from 21 AL patients analyzed by cytogenetics and interphase FISH.
  • Tested for numerical abnormalities of chromosomes 7, 11, 9, 15, 18, and X.
  • Monoclonal plasma cells identified via cytoplasmic immunoglobulin staining.

Main Results:

Related Experiment Videos

  • Multiple numerical chromosomal abnormalities detected in AL, including trisomies for chromosomes 7, 9, 11, 15, 18, and X.
  • Monosomy of chromosome 18 observed in 72% of AL cases.
  • No significant difference in abnormality prevalence between AL and MGUS.

Conclusions:

  • Interphase FISH identified multiple numerical chromosomal abnormalities in AL, notably chromosome 18 monosomy.
  • Aneuploidy in monotypic plasma cells suggests a neoplastic basis for AL.