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Related Experiment Videos

Diural TSH variations in hypothyroidism

J Weeke, P Laurberg

    The Journal of Clinical Endocrinology and Metabolism
    |July 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Thyroid-stimulating hormone (TSH) shows a diurnal variation in most hypothyroid patients, similar to euthyroid individuals. Severely hypothyroid patients lack this pattern, suggesting timing impacts TSH measurement accuracy.

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    Area of Science:

    • Endocrinology
    • Chronobiology
    • Thyroid Disorders

    Background:

    • Circadian variation in serum TSH is documented in euthyroid subjects.
    • Diurnal TSH patterns have also been observed in hypothyroid patients.

    Purpose of the Study:

    • To investigate the 24-hour serum TSH pattern in hypothyroid patients of varying severity.
    • To compare TSH patterns in treated and untreated hypothyroidism.
    • To assess the influence of hypothyroidism severity on TSH diurnal variation.

    Main Methods:

    • Investigated 24-hour serum TSH patterns.
    • Included eight patients with hypothyroidism of varying severity.
    • Included five hypothyroid patients treated with thyroxine (T4).

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    Main Results:

    • Circadian variation in serum TSH was observed in moderately hypothyroid patients.
    • Treated hypothyroid patients (for severe hypothyroidism) exhibited a similar diurnal TSH pattern to normal subjects (low daytime, high nighttime levels).
    • Severely hypothyroid patients showed no diurnal variation in serum TSH.

    Conclusions:

    • Serum TSH exhibits circadian variation in moderate hypothyroidism and in treated severe hypothyroidism.
    • The diurnal pattern of TSH in these groups resembles that of euthyroid individuals.
    • Blood sampling for TSH measurement in moderately hypothyroid patients is recommended after 1100 h to capture lower daytime levels.