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Sequence of a pyrimidine-selective Na+/nucleoside cotransporter from pig kidney, pkCNT1
1University of Arizona, Department of Physiology, College of Medicine, Tucson, AZ 85724-5051, USA.ampajor@utmb.edu
Biochimica Et Biophysica Acta
|December 22, 1998
Abstract:
A 3 kb cDNA called pkCNT1, a new member of the Na+/nucleoside cotransporter family, was cloned from pig kidney and sequenced. The sequence of pkCNT1 encodes a 647 amino acid protein that is 84% identical to the sequence of the rat pyrimidine-selective Na+/nucleoside cotransporter, rCNT1. pkCNT1 transports pyrimidines, such as thymidine and uridine, and has a Km for uridine of 9 microM.