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[Progressive multifocal leukoencephalopathy as initial manifestation of acquired immunodeficiency]
M A de Lima1, F V de Andrade, R M Etchebehere
1Trabalho realizado na Faculdade de Medicina do Triângulo Mineiro (FMTM), Uberaba, MG. lima@mednet.com.br
Abstract:
This is a report of a man with acquired immunodeficiency syndrome (AIDS) who presented acutely ill with severe progressive multifocal leukoencephalopathy (PML) as the first manifestation of AIDS. PML was diagnosed in the brain after gross and microscopical examination as well as by immunohistochemistry with an antibody against JC virus.
Insights
This case report details a man whose first sign of acquired immunodeficiency syndrome (AIDS) was severe progressive multifocal leukoencephalopathy (PML). Diagnosis of PML was confirmed via brain examination and JC virus immunohistochemistry.
Area of Science:
- Neurology
- Infectious Diseases
- Immunology
Background:
- Acquired immunodeficiency syndrome (AIDS) can present with opportunistic infections affecting the central nervous system.
- Progressive multifocal leukoencephalopathy (PML) is a rare, demyelinating disease of the central nervous system.
- PML is caused by the JC virus, typically in immunocompromised individuals.