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How to optimize therapeutic ratio in brachytherapy of head and neck squamous cell carcinoma?
J J Mazeron1, A Gerbaulet, J M Simon
1Centre des Tumeurs, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. jean-jacques.mazeron@psl.ap-hsp-paris.fr
Abstract:
Considerable experience has been accumulated with low dose rate (LDR) brachytherapy in the treatment of squamous cell carcinoma of the oral cavity and oropharynx, 4 cm or less in diameter. Recent analysis of large clinical series provided data indicating that modalities of LDR brachytherapy should be optimized in treating these tumours for increasing therapeutic ratio. LDR brachytherapy is now challenged by high dose rate (HDR) brachytherapy and pulsed dose rate (PDR) brachytherapy. Preliminary results obtained with the last two modalities are discussed in comparison with those achieved with LDR brachytherapy.