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Hormonal therapy in chronic radiation colitis

H Wurzer¹, I Schafhalter-Zoppoth, G Brandstätter

¹General Hospital of Graz, 2nd Medical Department, University Clinic of Surgery, Austria.

The American Journal of Gastroenterology

|December 22, 1998

Summary

Severe gastrointestinal bleeding from radiation colitis is rare but serious. Hormone therapy, specifically an estrogen-progesterone combination, effectively reduced blood transfusions and hospitalizations in a patient with this condition.

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Area of Science:

Oncology
Gastroenterology
Endocrinology

Background:

Radiation therapy for bladder cancer can lead to severe gastrointestinal bleeding.
Radiation colitis is a rare but significant complication requiring frequent blood transfusions.

Observation:

A patient with bladder cancer developed severe bleeding from radiation colitis.
The patient required 26 units of packed red cells over 5 months of treatment with multiple drugs.

Findings:

Subsequent hormone therapy with an estrogen-progesterone combination was administered.
This hormone therapy significantly decreased the patient's need for blood transfusions and hospitalizations.

Implications:

Hormone therapy may offer a promising additional symptomatic treatment for bleeding radiogenic colitis.

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Estrogen-progesterone combinations could be explored for managing radiation-induced gastrointestinal bleeding.