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A mAb recognizing a surface antigen of Mycobacterium tuberculosis enhances host survival
R Teitelbaum1, A Glatman-Freedman, B Chen
1Department of Microbiology and Immunology of the Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10064, USA.
Abstract:
Murine mAbs reactive with the surface of Mycobacterium tuberculosis were assayed for their ability to affect the course of infection in mice challenged with virulent organisms. An IgG3 mAb (9d8) specific for arabinomannan and reactive with purified antigen from a clinical isolate of M. tuberculosis conferred partial protection on mice after respiratory challenge (30-60% survival >75 days; P