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Related Experiment Video

Updated: Apr 29, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Diagnostics in onchocerciasis: future challenges

B A Boatin1, L Toé, E S Alley

  • 1World Health Organization/Onchocerciasis Control Programme in West Africa, Ouagadougou, Burkina Faso. boatin@ocp.oms.bf

Annals of Tropical Medicine and Parasitology
|December 23, 1998
PubMed
Summary
This summary is machine-generated.

Diagnosing onchocerciasis (river blindness) needs better methods than skin snipping. New tests like the diethylcarbamazine (DEC) patch test offer less invasive and more sensitive options for detecting this parasitic worm infection.

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Area of Science:

  • Medical Parasitology
  • Tropical Disease Diagnostics
  • Infectious Disease Epidemiology

Background:

  • The current standard for diagnosing onchocerciasis relies on skin biopsies to detect microfilariae, which has limitations.
  • This method is insufficient for early or light infections and is becoming less acceptable to affected populations.
  • Mectizan (ivermectin) treatment complicates diagnosis by reducing skin microfilariae, impacting the efficacy of the skin-snip technique.

Purpose of the Study:

  • To address the need for improved diagnostic tools for onchocerciasis.
  • To evaluate novel diagnostic approaches that are less invasive, more sensitive, and equally specific compared to the traditional skin-snip method.
  • To identify suitable adjuncts or replacements for current onchocerciasis diagnostic practices.

Main Methods:

  • Development and evaluation of new diagnostic assays for onchocerciasis.
  • Investigated an immunological assay utilizing a three-antigen cocktail.
  • Assessed a polymerase chain reaction (PCR)-based assay, including its potential for pool screening of blackflies.
  • Examined the diethylcarbamazine (DEC) patch test as a diagnostic tool.

Main Results:

  • The diethylcarbamazine (DEC) patch test emerged as a promising candidate, aligning well with the criteria for an ideal diagnostic test.
  • The PCR-based assay shows potential, particularly if its cost-effectiveness can be improved.
  • Immunological assays using a three-antigen cocktail are also under development.

Conclusions:

  • There is a critical need for advanced diagnostic methods for onchocerciasis beyond the conventional skin-snip approach.
  • The DEC patch test and PCR-based assays represent significant advancements in onchocerciasis diagnostics.
  • Further research into cost reduction for PCR could enhance its utility in onchocerciasis control programs.