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Updated: Jan 14, 2026
Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
Published on: May 14, 2018
A phase I-II study of bi-weekly paclitaxel as first-line treatment in metastatic breast cancer
K A Gelmon1, A Tolcher, S O'Reilly
1British Columbia Cancer Agency, Vancouver Centre, Canada.
Background:
Single-agent bi-weekly paclitaxel was studied as first-line metastatic treatment for breast cancer in a phase I-II trial.
Patients And Methods:
Thirty-eight women with metastatic breast cancer were enrolled. Thirty-seven are evaluable for toxicity, 35 for response.
Results:
The MTD was defined at 160 mg/m2 q two weeks with dose limiting toxicity in two patients consisting of hematological toxicity (1) and neurotoxicity (2). Twenty patients were treated at 150 mg/m2, the recommended dose. Response rates were two CRs and nine PRs (overall 61%) at the RD of 150 mg/m2 and three CRs and 11 PRs for an overall RR of 67% for the two top doses.
Conclusions:
The good drug tolerance, response rates, and convenience over weekly treatment suggest this may be a worthwhile regimen.
