Myotonia associated with hyperadrenocorticism in two dogs
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Updated: Oct 24, 2026

Myo-mechanical Analysis of Isolated Skeletal Muscle
Published on: February 22, 2011
G R Swinney1, S F Foster, D B Church
1Department of Veterinary Clinical Sciences, University of Sydney, New South Wales.
Abstract:
Two dogs developed a disabling gait abnormality characterised by stiffness. The abnormality was consistent with a diagnosis of myotonia secondary to hyperadrenocorticism. The first dog had iatrogenic hyperadrenocorticism, and its signs improved substantially after corticosteroid administration was gradually withdrawn. The second had pituitary-dependent hyperadrenocorticism, but myotonic signs progressed despite effective mitotane therapy. Procainamide administration reduced the myotonic stiffness in the second case.
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