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Product activation of human erythrocyte AMP deaminase
E V Mosharov1, V M Vitvitsky, F I Ataullakhanov
1Research Center for Hematology, Russian Academy of Medical Sciences, Moscow. john@blood.ru
FEBS Letters
|December 23, 1998
Abstract:
IMP was found to activate AMP deaminase in crude glucose-depleted human erythrocyte lysates. Activation of the enzyme by IMP is due to prevention of the inhibitory effect of inorganic phosphate. At 1 mM AMP and 2-3 mM phosphate the addition of 2-5 mM IMP accelerates the AMP deamination two to three times.