Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Smad4 (DPC4)--a potent tumour suppressor?

E K Duff1, A R Clarke

  • 1Department of Pathology, The University of Edinburgh Medical School, UK.

British Journal of Cancer
|December 23, 1998
PubMed
Summary

Smad4, a key molecule in transforming growth factor beta (TGF-beta) signaling, acts as a tumor suppressor. Loss of Smad4 function is linked to pancreatic and colorectal cancers, highlighting its role in malignancy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.

Oncogene·2024
Same author

A comprehensive phylogeny helps clarify the evolutionary history of host breadth and lure response in the Australian Dacini fruit flies (Diptera: Tephritidae).

Molecular phylogenetics and evolution·2022
Same author

Short communication: Effect of a citrus extract in lactating dairy cows.

Journal of dairy science·2017
Same author

Unisexual broods and sex ratios in a polyembryonic encyrtid parasitoid (Copidosoma sp.: Hymenoptera).

Oecologia·2017
Same author

Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.

Oncogene·2016
Same author

Apc and p53 interaction in DNA damage and genomic instability in hepatocytes.

Oncogene·2014

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Smad proteins are crucial mediators of transforming growth factor beta (TGF-beta) signaling pathways.
  • Seven Smad family members have been identified, each regulating TGF-beta superfamily gene transcription.
  • Smad2 and Smad4 (DPC4) are implicated in human cancer, exhibiting tumor-suppressor functions.

Purpose of the Study:

  • To review the current literature on the role of Smad4 in cancer development.
  • To highlight the association between Smad4 loss of function and various malignancies.

Main Methods:

  • Literature review of existing studies.
  • Analysis of research implicating Smad4 in cancer.

Main Results:

  • Loss of Smad4 function is strongly associated with pancreatic and colorectal cancers.
  • Evidence suggests Smad4 loss is linked to malignancy in other tissues as well.

Conclusions:

  • Smad4 is a central mediator in TGF-beta signaling with significant tumor-suppressor functions.
  • Smad4 inactivation is a critical factor in the development of several human cancers.

Related Experiment Videos