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Updated: Oct 26, 2026
Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
Published on: January 17, 2025
[Experimental study on effect of shenyi xieli mixture on nature killer cell activity and lymphocyte reactivity to
Objective:
To explore therapeutic mechanism of Shengyi Xieli Mixture (SYXLM) on malignant tumor.
Methods:
Chemotherapy, radiotherapy and different doses of SYXLM were used to treat tumor mice [correction of rats].
Results:
SYXLM could enhance the nature killer (NK) cell activities of the tumor mice [correction of rats], and this effect was dose dependent (control group 52.70 +/- 6.01, SYXLM No. 1 group 59.01 +/- 10.00, SYXLM No. 2 group 78.33 +/- 10.90, P < 0.01). The NK cell activities of the tumor mice [correction of rats] were inhibited in the chemotherapy group alone, but they were enhanced in the group of chemotherapy combined with SYXLM (P < 0.05), the results were the same in the radiotherapy group alone and the group of radiotherapy combined with SYXLM (P < 0.05). The response of lymphocyte of the tumor mice [correction of rats] to IL-2 was enhanced significantly in SYXLM group compared with the control group. This response was enhanced insignificantly in the group in which radiotherapy combined with the SYXLM.
Conclusion:
The SYXLM could enhance the function of immune system of the tumor mice [correction of rats] and diminish or reduce the side effect of radiotherapy, chemotherapy to the immune system of the tumor mice [correction of rats].
