[Diagnosis of Lyme neuroborreliosis]

Lyme neuroborreliosis is a disease of the central and/or peripheral nervous system caused by spirochete Borrelia burgdorferi. The diagnosis of Lyme neuroborreliosis is based on the clinical picture, differential diagnosis, serological tests with two-step approach and confirmation of positive results, monitoring of antibody titers and effects of adequate therapy. In failure revision of diagnosis is necessary, and if the diagnosis of Lyme neuroborreliosis is correct the effects of the therapy should patiently be expected. Relapse or reinfection are confirmed by new raise in titer of specific antibodies, new symptomatology and new antigens.