Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Epithelial cells in bronchial asthma]

V Djurić1, M Bogić, V Tomić

  • 1Institute of Allergology and Immunology, Clinical Centre of Serbia, Belgrade.

Srpski Arhiv Za Celokupno Lekarstvo
|December 24, 1998
PubMed
Summary

Asthma damages airway epithelium, impairing barrier function and mucus clearance. Eosinophils are increasingly recognized as key contributors to this epithelial damage in asthma.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decreased expression of MMP-9 in CD8<sup>+</sup> cells in placenta with severe preeclampsia.

Biotechnic & histochemistry : official publication of the Biological Stain Commission·2017
Same author

Does the BMI of Expectant Mothers Influence the Concentration of C-Reactive Protein in Newborns in the Early Neonatal Period?

Zeitschrift fur Geburtshilfe und Neonatologie·2016
Same author

Course of post-traumatic stress disorder following war in the Balkans: 1-year follow-up study.

Psychological medicine·2012
Same author

Trauma and suicidality in war affected communities.

European psychiatry : the journal of the Association of European Psychiatrists·2012
Same author

Health services and the treatment of immigrants: data on service use, interpreting services and immigrant staff members in services across Europe.

European psychiatry : the journal of the Association of European Psychiatrists·2012
Same author

Are somatosensory evoked potentials of the tibial nerve the most sensitive test in diagnosing multiple sclerosis?

Neurology India·2010

Area of Science:

  • Pulmonary Medicine
  • Cell Biology
  • Immunology

Context:

  • Asthma involves chronic airway inflammation.
  • Epithelial damage is a key feature of asthma pathology.
  • The role of eosinophils in asthma is under investigation.

Purpose:

  • To review current data on airway epithelial damage in asthma.
  • To describe the structure of normal airway epithelium.
  • To explore the mechanisms by which epithelial damage contributes to asthma.

Summary:

  • Airway epithelial damage in asthma disrupts the physical barrier, alters mucus secretion and mucociliary clearance, and promotes bronchoconstriction.
  • Epithelial cells play active roles in asthma by presenting antigens and recruiting inflammatory cells.
  • There is growing evidence supporting the hypothesis that eosinophils contribute significantly to airway epithelial damage in asthma.

Impact:

  • Understanding epithelial damage mechanisms in asthma can lead to targeted therapies.
  • Identifying the role of eosinophils may reveal new therapeutic targets for asthma.
  • This review highlights the epithelium as both a target and effector in asthma pathogenesis.

Related Experiment Videos