Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apoptosis in the kidney

M A Davis1, D H Ryan

  • 1Department of Pathology, School of Medicine, University of Maryland, Baltimore 21201, USA. mdavis@umaryland.edu

Toxicologic Pathology
|December 24, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nutritional and lifestyle supportive care recommendations for management of obesity with GLP-1 - based therapies: An expert consensus statement using a modified Delphi approach.

Obesity pillars·2026
Same author

Weight and cardiometabolic effects of a novel oral shape-shifting superabsorbent hydrogel capsule: Prespecified and exploratory analysis of the Epitomee capsule RESET study.

Obesity pillars·2025
Same author

The magnetic structure and spin-reorientation of ErGa.

Acta crystallographica Section B, Structural science, crystal engineering and materials·2024
Same author

Association between Family Household Income and Cognitive Resilience among Older US Adults: A Cross-Sectional Study.

The journal of prevention of Alzheimer's disease·2024
Same author

US Adults' Likelihood to Participate in Dementia Prevention Drug Trials: Results from the National Poll on Healthy Aging.

The journal of prevention of Alzheimer's disease·2023
Same author

Magnetic crystalline-symmetry-protected axion electrodynamics and field-tunable unpinned Dirac cones in EuIn<sub>2</sub>As<sub>2</sub>.

Nature communications·2021
Same journal

New Approach Methodologies (NAMs) for Carcinogenicity Evaluation.

Toxicologic pathology·2026
Same journal

2025 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: Pathology Working Groups (PWGs) in Toxicologic Pathology.

Toxicologic pathology·2026
Same journal

Toxicologic Pathology Forum*: Opportunities and Challenges in the Use of Artificial Intelligence in Nonclinical Toxicologic Histopathology Evaluations.

Toxicologic pathology·2026
Same journal

New Modalities and Carcinogenicity Assessment.

Toxicologic pathology·2026
Same journal

Second Joint Annual Congress of the British Society of Toxicologic Pathology and the European Society of Toxicologic Pathology Special Issue.

Toxicologic pathology·2026
Same journal

Hemangiosarcomas in Intercostal Brown Adipose Tissues of the Sternum Induced by Urethane in TgrasH2 Mice.

Toxicologic pathology·2026
See all related articles

Apoptosis, a regulated cell death, is crucial for kidney homeostasis. Aberrant apoptosis induced by toxicants can lead to kidney disease and cancer.

Area of Science:

  • Nephrology
  • Toxicology
  • Cell Biology

Background:

  • Apoptosis is a fundamental biological process essential for normal development and tissue maintenance.
  • Dysregulation of apoptosis, particularly in the kidney, can contribute to disease pathogenesis.
  • Environmental toxicants can interfere with cellular processes, including apoptosis.

Purpose of the Study:

  • To review the role of apoptosis in normal kidney development.
  • To examine the involvement of apoptosis in the progression of renal diseases.
  • To discuss toxicants and molecular regulators implicated in renal cell apoptosis.

Main Methods:

  • Literature review of scientific publications on apoptosis, kidney development, renal disease, and toxicology.
  • Analysis of molecular mechanisms regulating apoptosis in renal cells.

Related Experiment Videos

  • Identification of environmental factors and toxicants associated with aberrant apoptosis in the kidney.

    • Main Results:

    • Apoptosis plays a critical role in kidney development and homeostasis.
    • Aberrant apoptosis induced by low-level toxicant exposure can disrupt kidney function.
    • This disruption is linked to the development of renal neoplasia and other kidney diseases.

    Conclusions:

    • Understanding the regulation of apoptosis in renal cells is vital for comprehending kidney disease.
    • Toxicant-induced apoptosis represents a significant risk factor for renal pathology.
    • Further research into molecular regulators and specific toxicants is warranted for therapeutic strategies.