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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Apoptosis in the kidney

M A Davis1, D H Ryan

  • 1Department of Pathology, School of Medicine, University of Maryland, Baltimore 21201, USA. mdavis@umaryland.edu

Toxicologic Pathology
|December 24, 1998
PubMed

Insights

Apoptosis, a regulated cell death, is crucial for kidney homeostasis. Aberrant apoptosis induced by toxicants can lead to kidney disease and cancer.

Area of Science:

  • Nephrology
  • Toxicology
  • Cell Biology

Background:

  • Apoptosis is a fundamental biological process essential for normal development and tissue maintenance.
  • Dysregulation of apoptosis, particularly in the kidney, can contribute to disease pathogenesis.
  • Environmental toxicants can interfere with cellular processes, including apoptosis.

Purpose of the Study:

  • To review the role of apoptosis in normal kidney development.
  • To examine the involvement of apoptosis in the progression of renal diseases.
  • To discuss toxicants and molecular regulators implicated in renal cell apoptosis.

Main Methods:

  • Literature review of scientific publications on apoptosis, kidney development, renal disease, and toxicology.
  • Analysis of molecular mechanisms regulating apoptosis in renal cells.
  • Identification of environmental factors and toxicants associated with aberrant apoptosis in the kidney.

Main Results:

  • Apoptosis plays a critical role in kidney development and homeostasis.
  • Aberrant apoptosis induced by low-level toxicant exposure can disrupt kidney function.
  • This disruption is linked to the development of renal neoplasia and other kidney diseases.

Conclusions:

  • Understanding the regulation of apoptosis in renal cells is vital for comprehending kidney disease.
  • Toxicant-induced apoptosis represents a significant risk factor for renal pathology.
  • Further research into molecular regulators and specific toxicants is warranted for therapeutic strategies.

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