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Soluble tumor necrosis factor alpha receptors in sera from leprosy patients
M E Munk1, P Anding, A P Schettini
1Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany. munk@mpiib-berlin.mpg.de
Infection and Immunity
|December 24, 1998
Abstract:
Serum levels of soluble tumor necrosis factor alpha receptor I (sTNF-RI) were elevated in patients with lepromatous (LL) reactional-state type II leprosy, and sTNF-RII levels were increased in patients with full tuberculoid (TT) or LL type II leprosy. The sTNF-R in sera from patients with type II leprosy, but not other forms of leprosy, inhibited recombinant TNF cytolytic activities in vitro. This suggests that sTNF-R regulatory activities are partially impaired in patients with leprosy.