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Nonrestricted differential intoxication of cells by pertussis toxin
A el Bayâ1, K Brückener, M A Schmidt
1Institut für Infektiologie - Zentrum für Molekularbiologie der Entzündung, Westfälische Wilhelms-Universität Münster, Germany.
Infection and Immunity
|December 24, 1998
Abstract:
After uptake and retrograde transport pertussis toxin acts by ADP-ribosylating alpha-Gi proteins. We show that uptake via many different receptor proteins followed by retrograde transport and intoxication is not restricted to a particular cell type. The efficiency of cellular intoxication, however, was found to be cell type dependent.