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Gamma delta T-cell function in pathogenesis of cerebral malaria in mice infected with Plasmodium berghei ANKA

D M Yañez¹, J Batchelder, H C van der Heyde

¹Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison 53706, USA.

Infection and Immunity

|December 24, 1998

Abstract:

Mice depleted of gammadelta T cells by monoclonal antibody treatment and infected with Plasmodium berghei ANKA did not develop cerebral malaria (CM). In striking contrast, delta0/0 mice infected with P. berghei developed CM despite their gammadelta T-cell deficiency. gammadelta T cells appear to be essential for the pathogenesis of CM in mice having experienced normal ontogeny but not in mice genetically deprived of gammadelta T cells from the beginning of life.

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