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Prospective study of nonsteroidal anti-inflammatory drugs and breast cancer
R E Harris1, S Kasbari, W B Farrar
1The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Abstract:
We conducted a prospective cohort study of Nonsteroidal anti-inflammatory drugs (NSAIDs) and breast cancer among 32,505 women in central Ohio, USA. After 5 years of follow-up, a total of 393 cases have been detected. The annual incidence of breast cancer per 100,00 women varied inversely with increasing intake of NSAIDs, declining from 323 among non-users to 183 among heavy users (p<0.01). Breast cancer rates decreased by about 50% with regular ibuprofen intake (p<0.01), and by about 40% with regular aspirin intake (p<0.05). The results suggest that specific NSAIDs may be effective chemopreventive agents against breast cancer.
Insights
Regular use of Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and aspirin may significantly lower breast cancer risk. This study found a notable decline in incidence among women with higher NSAID intake.
Area of Science:
- Oncology
- Epidemiology
- Pharmacology
Background:
- Breast cancer is a leading cause of mortality in women globally.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation.
- Previous research has suggested a potential link between NSAID use and reduced cancer risk.
Purpose of the Study:
- To investigate the association between Nonsteroidal anti-inflammatory drugs (NSAIDs) consumption and breast cancer incidence.
- To quantify the risk reduction associated with regular use of specific NSAIDs, such as ibuprofen and aspirin.
Main Methods:
- A prospective cohort study involving 32,505 women in central Ohio, USA.
- Follow-up duration of 5 years to track breast cancer diagnoses.
- Analysis of breast cancer incidence rates based on varying levels of NSAID intake.
Main Results:
- A significant inverse relationship was observed between NSAID intake and breast cancer incidence (p<0.01).
- Breast cancer rates decreased from 323 to 183 per 100,000 women with increasing NSAID use.
- Regular ibuprofen intake was associated with a ~50% reduction in breast cancer rates (p<0.01), and regular aspirin intake with a ~40% reduction (p<0.05).
Conclusions:
- Specific NSAIDs, including ibuprofen and aspirin, may serve as effective chemopreventive agents against breast cancer.
- Findings support the potential role of regular NSAID use in reducing breast cancer risk.
- Further research is warranted to elucidate the mechanisms and confirm these findings.