[Kikuchi-Fujimoto subacute necrotizing lymphadenitis: two histologic forms observed in the same patient]
Related Experiment Video
Updated: Oct 26, 2026

Optimized Workflow for Iterative Bleaching Extends Multiplexity Imaging of Highly Autofluorescent Clinical Samples
Published on: July 11, 2025
F el Mezni1, K Mrad, A el Mezni-Benzarti
1Service d'Anatomie Pathologique, Hôpital Charles-Nicolle, Tunis, Tunisie.
Abstract:
Histiocytic necrotizing lymphadenitis, also known as Kikuchi-Fujimoto disease is a rare self-limited condition of young adults usually misdiagnosed as malignant hematologic disease. The diagnosis depends on microscopic findings. Two histologic types are classically described, proliferative and necrotic types. This is a case report of 17 year-old girl who presented cervical lymphadenopathy. The first lymph node biopsy was in favor of malignant lymphoma. The second lymph node biopsy, done one month later, showed typical histiocytic necrotizing lymphadenitis. To our knowledge, this is the first time that the two forms of this disease are described in the same patient.