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[Asthma and infection: risk or prevention?]
1Haunersche Kinderklinik, Klinikum Innenstadt, München. Von.Mutius@kk-i.med.uni-muenchen.de
Schweizerische Medizinische Wochenschrift
|December 29, 1998
Summary
Respiratory infections in early childhood are common and linked to wheezing illnesses. While viruses like RSV and rhinovirus are often implicated, some studies suggest infections may reduce allergy risks.
Area of Science:
- Pediatric respiratory health
- Infectious disease epidemiology
- Immunology
Context:
- Early childhood respiratory infections and wheezing illnesses are prevalent.
- Viral pathogens like RSV, rhinovirus, influenza, and parainfluenza are key contributors.
- Advancements in PCR techniques have improved viral detection rates in respiratory illnesses.
Purpose:
- To explore the association between early life respiratory infections and subsequent respiratory abnormalities.
- To investigate the role of viral infections in childhood wheezing illnesses.
- To examine potential links between early infections and atopic sensitization.
Summary:
- Viral infections in early childhood are frequently associated with wheezing illnesses.
- Rhinovirus is a predominant virus identified in asthmatic children with wheezing episodes.
- Two hypotheses explain the link: lung damage/immune alteration or underlying predisposition.
- Conversely, early infections might decrease the risk of atopic sensitization and allergies.
Impact:
- Clarifies the complex relationship between viral infections and respiratory health outcomes in children.
- Highlights the importance of identifying specific viral agents in wheezing illnesses.
- Suggests potential protective effects of early infections against allergic conditions, warranting further research.