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[Coagulation system in patients with blood malignancies treated with estrogens in the course of cytostatic therapy]
Aim:
To evaluate the effect of estrogen gestagenic drugs (EGD) on blood coagulation in patients with blood malignancies treated by polychemotherapy.
Materials And Methods:
32 females of reproductive age treated with ovarioprotector marvelon during cytostatic therapy. The following indices were determined: activated partial thrombin time, prothrombin index of the ethanol test, fibrinogen and antithrombin III levels, factor XIIa dependent time of fibrinolysis, thrombin time. Dopplerography of the lower limb vessels was carried out.
Results:
No significant alterations in coagulograms of the patients treated with cytostatics in combination with EGD were recorded.
Conclusion:
It is safe to use EGD as ovarioprotectors in females with hematological malignancies in hypercoagulation.