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Related Experiment Videos

[Hypotension in acyclovir therapy]

H Wolters1, A Mayer, U Gerhardt

  • 1Medizinische Poliklinik, Universität Münster.

Praxis
|December 29, 1998
PubMed
Summary
This summary is machine-generated.

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Aciclovir treatment for Herpes zoster led to bradycardia and hypotension in a cancer patient. Symptoms resolved after discontinuing the antiviral drug, suggesting a reversible autonomic neuropathy.

Area of Science:

  • Neurology
  • Oncology
  • Pharmacology

Background:

  • A 51-year-old male with a history of advanced head and neck cancer (hypopharyngeal carcinoma) presented with Herpes zoster.
  • The patient had undergone multiple surgeries for cancer recurrence and metastasis.

Observation:

  • During intravenous aciclovir treatment for Herpes zoster, the patient experienced recurrent episodes of bradycardia (slow heart rate) and hypotension (low blood pressure).
  • Diagnostic tests, including tilt-table testing, were performed. Investigations ruled out direct nerve infiltration or structural abnormalities.
  • Significantly reduced serum catecholamine levels were noted during the symptomatic episodes.

Findings:

  • Cessation of aciclovir therapy resulted in the complete resolution of bradycardia and hypotensive episodes.

Related Experiment Videos

  • Tilt-table testing after aciclovir cessation was unremarkable, indicating a return to normal autonomic function.

    • Implications:

    • This case suggests that aciclovir may induce a reversible autonomic neuropathy.
    • Clinicians should consider antiviral-induced autonomic dysfunction in patients presenting with unexplained bradycardia and hypotension, especially those with a history of malignancy.