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Type I interferon gene expression: differential expression of IFN-A genes induced by viruses and double-stranded RNA
1UPR 37-CNRS, Laboratoire de Régulation de l'Expression des Gènes Eucaryotes, UFR Biomédicale des Saints-Pères, Université Paris V, France.
Abstract:
The family of interferon regulatory transcription factors (IRF) participates in the virus-induced and dsRNA-stimulated transcriptional regulation of either type I IFN genes or a definite set of genes which can also be activated by IFN. In this review, we place emphasis on the role of IRF-3 that associates with the coactivators CBP and/or p300, together or not with IRF-7. These complexes bind to the PRDI, PRDI-like domains or to a number of ISRE sequences located in the promoter of these virus-inducible genes. We also discuss the involvement of the IRF-3-related complexes in the differential regulation of IFN-A genes.