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Respiratory work in elastase treated hamsters

K J Sullivan1, M Fournier, M I Lewis

  • 1Department of Medicine, The Burns and Allen Research Institute, Cedars-Sinai Medical Center, University of California Los Angeles School of Medicine, 90048, USA.

Respiration Physiology
|December 29, 1998
PubMed
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Diaphragm adaptations in emphysema hamsters differ from exercise training. Dynamic pressure-volume work of breathing in elastase-induced emphysema did not significantly alter total work of breathing, suggesting other mechanisms are involved.

Area of Science:

  • Pulmonary Physiology
  • Respiratory Mechanics
  • Emphysema Research

Background:

  • Diaphragm biomechanical adaptations in emphysema models resemble those in exercise-trained skeletal muscle.
  • The role of dynamic pressure-volume (PV) work of breathing in these adaptations remains unclear.

Purpose of the Study:

  • To investigate if dynamic PV work of breathing contributes to diaphragm adaptations in a hamster model of emphysema.
  • To compare PV work in elastase-treated hamsters with healthy controls.

Main Methods:

  • Adult hamsters received intratracheal elastase or saline (control).
  • Measurements included airway/esophageal pressures and airflows during spontaneous breathing.
  • Pulmonary work (WL) was calculated from transpulmonary pressures and airflows.

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Main Results:

  • Elastase-treated (ET) hamsters showed increased functional residual capacity (FRC) and total lung capacity (TLC).
  • Tidal volume (VT) and inspiratory flows were similar between ET and control groups.
  • Pulmonary elastance work (WE) was significantly lower in ET animals, while total work of breathing (WT) per VT and pulmonary resistive work were not significantly different.

Conclusions:

  • Dynamic mechanical properties of the lung in elastase-induced emphysema do not appear to be the primary driver of diaphragm biomechanical adaptations.
  • Mechanisms other than altered dynamic lung mechanics likely underlie the observed diaphragm adaptations in this emphysema model.