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Related Experiment Videos

Exhaled nitric oxide in preterm infants

A Artlich1, T Busch, K Lewandowski

  • 1Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden. andreas.artlich@fyfa.ki.se

Respiration Physiology
|December 29, 1998
PubMed
Summary
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Exhaled nitric oxide (NO) levels are lower in preterm infants compared to adults, suggesting limited paranasal sinus contribution. However, body weight-normalized NO excretion remains comparable, indicating other sources may be significant.

Area of Science:

  • Neonatal Physiology
  • Respiratory Medicine
  • Biomedical Science

Background:

  • Nitric oxide (NO) in exhaled breath is primarily attributed to paranasal sinuses in adults.
  • Preterm infants have underdeveloped paranasal sinuses, prompting investigation into NO origins in this population.

Purpose of the Study:

  • To measure total nitric oxide (NO) excretion rates in preterm infants.
  • To compare NO excretion in preterm infants with existing data from older children and adults.

Main Methods:

  • Chemiluminescence was used to measure nitric oxide (NO) excretion rates.
  • Measurements were taken from spontaneously exhaled nasal gas and lower airways of intubated preterm infants.

Main Results:

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  • NO excretion from nasal gas in preterm infants was 7.15 ± 1.13 nl/min.
  • NO excretion from lower airways in intubated infants was significantly lower at 0.3 ± 0.05 nl/min.
  • These values are considerably lower than those reported for adults, but body weight-related amounts appear comparable.

    • Conclusions:

    • Exhaled nitric oxide (NO) levels in preterm infants are lower than in adults, suggesting a reduced contribution from paranasal sinuses.
    • Body weight-normalized NO excretion in preterm infants may be comparable to adults, hinting at potential alternative NO sources.
    • Further research is needed to fully elucidate the origins and significance of nitric oxide in neonatal respiration.