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Chloroquine inhibits HIV-1 replication in human peripheral blood lymphocytes
W M Pardridge1, J Yang, A Diagne
1Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1682, USA. wpardrid@med1.medsch.ucla.edu
Immunology Letters
|December 29, 1998
Abstract:
Chloroquine has inhibitory effects on human immunodeficiency deficiency virus (HIV)-1 replication in human lymphocytes with an ED50 of 15 microM, which approximates the chloroquine plasma concentration generated in the acute treatment of malaria. Chloroquine has a parallel inhibitory effect on DNA replication in human lymphocytes, although the inhibitory effect on DNA replication is not as pronounced as is the drug inhibition of HIV-1 replication in the cells.