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Related Concept Videos

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Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Laminins are the Adhesive Proteins of Basal Lamina00:55

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Updated: Jul 14, 2026

Cell Membrane Repair Assay Using a Two-photon Laser Microscope
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A role for dystroglycan in basement membrane assembly

M D Henry1, K P Campbell

  • 1Howard Hughes Medical Institute, Department of Physiology and Biophysics, The University of Iowa College of Medicine, Iowa City 52242, USA.

Cell
|December 29, 1998
PubMed
Summary

Dystroglycan is essential for basement membrane formation in vivo. This cell-surface laminin receptor organizes laminin, enabling the deposition of other extracellular matrix proteins for proper basement membrane assembly.

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Area of Science:

  • Cell biology
  • Extracellular matrix
  • Developmental biology

Background:

  • Basement membranes are crucial extracellular matrix structures.
  • Their in vivo assembly mechanisms remain poorly understood.
  • Dystroglycan is a cell-surface laminin receptor.

Purpose of the Study:

  • To investigate the function of dystroglycan in basement membrane assembly.
  • To elucidate the role of dystroglycan-laminin interactions in this process.

Main Methods:

  • Utilized embryoid bodies as a model system.
  • Investigated the requirement of dystroglycan for basement membrane formation.
  • Examined the impact of dystroglycan on other basement membrane protein deposition.

Main Results:

  • Dystroglycan is essential for basement membrane formation in embryoid bodies.
  • Dystroglycan-laminin interactions are a prerequisite for the deposition of other basement membrane proteins.
  • Dystroglycan may organize basement membrane assembly by binding and presenting soluble laminin on the cell surface.

Conclusions:

  • Dystroglycan plays a critical role in the in vivo assembly of basement membranes.
  • Dystroglycan-laminin interactions are fundamental to basement membrane formation.
  • This study suggests key mechanisms for how cells contribute to building basement membranes.