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Related Experiment Videos

Microbiologic characteristics of persistent otitis media

I Brook1, A E Gober

  • 1Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA.

Archives of Otolaryngology--Head & Neck Surgery
|December 29, 1998
PubMed
Summary
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Identifying pathogens in children with acute otitis media unresponsive to antibiotics is crucial. Antimicrobial resistance was common, highlighting the need for diagnostic tympanocentesis to guide treatment.

Area of Science:

  • Pediatric Infectious Diseases
  • Microbiology
  • Antimicrobial Resistance

Background:

  • Acute otitis media (AOM) is a common childhood infection.
  • Treatment failure in AOM can be linked to pathogen characteristics and antimicrobial resistance.

Purpose of the Study:

  • To identify pathogens causing AOM in children who did not respond to antibiotic treatment.
  • To investigate the prevalence of antimicrobial resistance in these pathogens.

Main Methods:

  • Retrospective analysis of tympanocentesis cultures from 46 children with AOM.
  • Identification of bacterial isolates and assessment of antimicrobial susceptibility.

Main Results:

  • Pathogens were recovered from 74% of children; Streptococcus pneumoniae and Haemophilus influenzae were most common.

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  • Antimicrobial resistance was observed in 63% of isolates.
  • Haemophilus influenzae predominated in amoxicillin treatment failures; Streptococcus pneumoniae was frequent in failures of other antibiotics.

    • Conclusions:

    • Antimicrobial resistance is associated with treatment failure in pediatric AOM.
    • Diagnostic tympanocentesis is essential for identifying resistant pathogens and optimizing therapy.