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Drugs causing fixed eruptions: a study of 450 cases
1Department of Dermatology, King Edward Medical College/Mayo Hospital, Lahore, Pakistan.
International Journal of Dermatology
|December 29, 1998
Summary
Fixed drug eruption (FDE) is a common skin reaction. Cotrimoxazole is the most frequent cause, though FDE can present in various ways and new drug associations were identified.
Area of Science:
- Dermatology
- Pharmacology
- Clinical Medicine
Background:
- Drug eruptions are common dermatological conditions.
- Fixed drug eruption (FDE) is characterized by recurrent lesions at the same site.
- FDE can cause significant cosmetic concerns for patients.
Purpose of the Study:
- To identify the causative agents of fixed drug eruption (FDE).
- To analyze the clinical presentations of FDE.
- To report novel drug associations with FDE.
Main Methods:
- Retrospective analysis of 450 patients diagnosed with FDE.
- Documentation of patient demographics, clinical presentation, and implicated drugs.
- Literature review for previously reported drug-induced FDE.
Main Results:
- The study analyzed 450 FDE patients with a near equal male to female ratio (1:1.1).
- The most common presentation was circular hyperpigmented lesions, but FDE exhibited diverse morphologies including erythema, urticaria, and hypermelanosis.
- Cotrimoxazole was identified as the most frequent causative drug. New associations were found with diclofenac sodium, pyrantel pamoate, clindamycin, and albendazole.
Conclusions:
- Cotrimoxazole is the leading cause of FDE.
- Fixed drug eruption (FDE) presents with varied clinical manifestations.
- This study reports, for the first time, FDE associated with diclofenac sodium, pyrantel pamoate, clindamycin, and albendazole.