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Postheparin-diamine oxidase (histaminase) in anaphylaxis
Klinische Wochenschrift
|March 15, 1978
Summary
Anaphylactic shock significantly depletes plasma postheparin-diamine oxidase levels in patients. Enzyme levels recover slowly over six months, suggesting depletion in the liver and small intestine.
Area of Science:
- Biochemistry
- Immunology
- Pharmacology
Background:
- Anaphylaxis is a severe allergic reaction with complex physiological consequences.
- Postheparin-diamine oxidase (PHDAO) is an enzyme involved in histamine metabolism.
- The role of PHDAO in anaphylaxis has not been extensively studied in humans.
Observation:
- Plasma PHDAO levels were measured in two patients following anaphylactic shock.
- Enzyme levels were assessed at three days, four weeks, and six months post-event.
- A control group was used for comparison.
Findings:
- Three days after anaphylaxis, plasma PHDAO levels were approximately 10% of control levels.
- By six months, PHDAO levels showed a partial recovery, reaching about 40% of control values.
- This indicates a significant and prolonged depletion of PHDAO following anaphylactic shock.
Implications:
- The findings suggest that anaphylaxis leads to a depletion of PHDAO, likely in the liver and small intestine.
- This depletion may impair histamine breakdown, potentially exacerbating anaphylactic symptoms.
- Further research in animal models supports PHDAO depletion after heparin administration, relevant to anaphylaxis mechanisms.