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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

[Immunity of middle age and aged patients with tuberculosis and its changes during multimodality treatment by using

D A Adambekov, V I Litvinov, K B Mambetov

    Problemy Tuberkuleza
    |December 29, 1998
    PubMed

    Fifty six patients with pulmonary tuberculosis were examined. Of them 30 had T-activin in multimodality treatment. To supplement the agent in elderly and old patients was found to elevate the counts of T lymphocytes and T helper cells, to normalize Tx/Tc ratios, to enhance T lymphocytic activity and IL-2 synthesis. At the same time there was an increase in nonspecific responsiveness: enhancement of NKC activity and IL-1 synthesis by macrophages. With this, stimulation of specific antituberculous immunity took place. Normalization of immunological responsiveness and stimulation of specific antituberculous immunity were associated with enhanced therapeutical efficiency.

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