[Oxidative metabolic changes, antioxidantion, and platelet activation rat phagocytes during development of...

An experiment was made on 100 noninbred albino rats, of which 80 rats were intraperitoneally inoculated by Mycobacterium tuberculosis (MT) in a dose of 7.5 mg. Examinations were conducted 1 day, 1, 2, and 8 weeks after inoculation. Alveolar macrophages, nonfractionated cellular sediment of bronchoalveolar lavage, and leukocytes were the object of the studies. Spontaneous and BCG-stimulated HCT test, the activities of superoxide dismutase (SOD) and catalase, the content of malonic dialdehyde (MDA), and platelet activation factor (PAF) were determined in all cell populations. The course of the process was histologically controlled. Following a fortnight, specific foci developed in the organs, they began spontaneously resolving 6 weeks later. In all types of cells, an infectious process resulted in an increase in the rate of oxidative metabolism, which did not lead to their functional exhaustion. In early infection, the activity of SOD dropped, the level of MDA and the activity of catalase increased. During involution of specific changes, their normalization of MDA and catalase variables corresponded to the high values of SPD in the cells. The level of PAF moderately elevated during the formation of specific changes in the organs and fell below the control values in the involutional phase of the process.