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Normal values for left ventricular volumes obtained using gated PET

H L Boyd1, S D Rosen, O Rimoldi

  • 1MRC Cyclotron Unit, Hammersmith Hospital, London, United Kingdom.

Giornale Italiano Di Cardiologia
|December 29, 1998
PubMed
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This study establishes normal left ventricular (LV) volumes using Positron Emission Tomography (PET) with C15O, providing crucial reference data for heart disease assessment. These normal values aid in diagnosing conditions involving LV dilation.

Area of Science:

  • Cardiovascular Imaging
  • Nuclear Medicine
  • Physiology

Background:

  • Accurate left ventricular (LV) volume assessment is vital for understanding myocardial function, especially in conditions causing LV dilation like post-myocardial infarction remodeling.
  • Positron Emission Tomography (PET) with oxygen-15 labeled carbon monoxide (C15O) has been validated for measuring LV volumes.
  • Establishing normal LV volume values is essential for clinical interpretation.

Purpose of the Study:

  • To establish normal values for left ventricular (LV) end-diastolic volume (EDV) and end-systolic volume (ESV) in absolute units.
  • To utilize a validated gated Positron Emission Tomography (PET) technique with C15O for this standardization.
  • To provide a reference database for comparing pathological cardiac conditions.

Main Methods:

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  • Forty healthy subjects (21 males, 19 females; age 49 ± 13 years) were studied.
  • LV volumes (EDV and ESV) were calculated using gated PET with C15O.
  • Volumes were determined by delineating the blood pool on end-diastolic and end-systolic images.

Main Results:

  • Overall study population: EDV 109 ± 20 ml, ESV 37 ± 12 ml.
  • Gender stratification: Males (EDV 117 ± 18 ml, ESV 42 ± 18 ml), Females (EDV 100 ± 19 ml, ESV 32 ± 8 ml).
  • Gender-based differences in EDV (p=0.0027) and ESV (p=0.0029) were resolved upon correction for body surface area (BSA).

Conclusions:

  • The study provides a database of normal LV volumes using PET with C15O.
  • This data serves as a benchmark for assessing cardiac pathologies involving LV volume changes.
  • PET offers a comprehensive imaging modality for LV volume assessment, alongside regional myocardial perfusion and metabolism evaluation.