Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Physiologic responses to primary blast

R J Guy1, E Kirkman, P E Watkins

  • 1Medical Countermeasures, CBD Porton Down, Salisbury, Wiltshire, England.

The Journal of Trauma
|December 29, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Short- and long-term outcomes of strictureplasty for obstructive Crohn's disease.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2020
Same author

Dysregulation of the actin scavenging system and inhibition of DNase activity following severe thermal injury.

The British journal of surgery·2019
Same author

Transfusion on the Burma Railway: The life of Jacob Markowitz.

Journal of medical biography·2019
Same author

The Association of Coloproctology of Great Britain and Ireland consensus guidelines in surgery for inflammatory bowel disease.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2018
Same author

Nebulised recombinant activated factor VII (rFVIIa) does not attenuate the haemorrhagic effects of blast lung injury.

Journal of the Royal Army Medical Corps·2018
Same author

A diagnostic evaluation of a molecular assay used for testing and treating anorectal chlamydia and gonorrhoea infections at the point-of-care in Papua New Guinea.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2018
Same journal

Article.

The Journal of trauma·2014
Same journal

Article.

The Journal of trauma·2014
Same journal

Program schedule for the sixty-fifth annual meeting of the american association for the surgery of trauma.

The Journal of trauma·2014
Same journal

Letters to the editor.

The Journal of trauma·2014
Same journal

Posttraumatic brachial plexitis.

The Journal of trauma·2011
Same journal

Incidental findings in focused assessment with sonography for trauma in hemodynamically stable blunt trauma patients: speaking about cost to benefit.

The Journal of trauma·2011
See all related articles

Moderate thoracic blast exposure causes a reflex triad of apnea, bradycardia, and hypotension in rats. This response was not observed with abdominal blast exposure, offering insights into blast injury management.

Area of Science:

  • Physiology
  • Trauma Research
  • Cardiorespiratory System

Background:

  • Primary blast injuries result from shock waves.
  • Pulmonary injury is critical for survival after blast exposure.
  • Acute cardiorespiratory responses to blast are not fully understood.

Purpose of the Study:

  • To investigate acute cardiorespiratory responses to blast exposure.
  • To understand the effects of thoracic versus abdominal blast exposure.
  • To identify potential physiological mechanisms in blast injury.

Main Methods:

  • Anesthetized rats were exposed to moderate blast overpressure (thoracic or abdominal).
  • Cardiorespiratory parameters (respiration, heart rate, blood pressure) were continuously monitored.

Related Experiment Videos

  • Control group received no blast exposure.

    • Main Results:

    • Thoracic blast exposure induced apnea, bradycardia, and hypotension.
    • These cardiorespiratory changes in the thoracic group returned to baseline.
    • Abdominal blast exposure did not cause significant cardiovascular or respiratory changes.

    Conclusions:

    • Moderate thoracic blast injury triggers a specific reflex triad (apnea, bradycardia, hypotension).
    • This reflex response is unique to thoracic blast injury, not seen with abdominal blast.
    • Findings have implications for immediate clinical management of blast-injured patients.