Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human and experimental hepatocarcinogenesis

Z Schaff1, I Kovalszky, P Nagy

  • 1First Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest, Hungary.

Scandinavian Journal of Gastroenterology. Supplement
|December 29, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corticothalamic feedback locally modulates network state.

Scientific reports·2025
Same author

Double rarity: malignant masquerade biliary stricture in a situs inversus totalis patient.

BMC surgery·2021
Same author

KIT Mutation Incidence and Pattern of Melanoma in Central Europe.

Pathology oncology research : POR·2019
Same author

Characterisation of bioenergetic pathways and related regulators by multiple assays in human tumour cells.

Cancer cell international·2016
Same author

DNA fragmentation and caspase-independent programmed cell death by modulated electrohyperthermia.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2014
Same author

Mating type loci inFusarium: structure and function.

Mycotoxin research·2013
Same journal

Abstract from the 41st Nordic Gastroenterology Congress, 8-11 June 2010, Copenhagen, Denmark.

Scandinavian journal of gastroenterology. Supplement·2010
Same journal

Abstracts from the XL Nordic Meeting of Gastroenterology, June 8-11, 2009, Stavanger, Norway.

Scandinavian journal of gastroenterology. Supplement·2009
Same journal

Abstracts of the 39th Nordic Meeting of Gastroenterology, 30th Nordic Meeting of Digestive Endoscopy, 18th Nordic Meeting of Gastrointestinal Motility, and the Annual Endoscopy/Gastroenterology Nurses'/Assistants' Meeting Post-graduate course, 4-6 June 2008, Helsinki, Finland.

Scandinavian journal of gastroenterology. Supplement·2008
Same journal

Abstracts from the XXXVIII Nordic Meeting of Gastroenterology, XXIX Nordic Meeting of Digestive Endoscopy, XVII Nordic Meeting of Gastrointestinal Motility, 6-9 June 2007, Reykjavik, Iceland.

Scandinavian journal of gastroenterology. Supplement·2007
Same journal

Abstracts of the XXXVII Nordic Meeting of Gastroenterology, 3-5 May 2006, Vasteras, Sweden.

Scandinavian journal of gastroenterology. Supplement·2006
Same journal

Novel approaches in the outpatient care of patients with chronic inflammatory bowel disease.

Scandinavian journal of gastroenterology. Supplement·2006
See all related articles

Understanding liver cancer progression is crucial. Animal models reveal early changes in liver tumors, aiding human disease research and early detection strategies.

Area of Science:

  • Hepatology and Carcinogenesis
  • Comparative Pathology
  • Oncology

Background:

  • Human liver cancer incidence is rising globally, necessitating early detection for effective treatment.
  • Premalignant and early malignant liver lesions require better understanding for therapeutic intervention.
  • Existing animal models offer insights into liver tumor development and progression.

Purpose of the Study:

  • To compare experimentally induced hepatomas with human liver lesions.
  • To identify common molecular and phenotypic changes in liver cancer development.
  • To evaluate the utility of animal models in studying human liver cancer.

Main Methods:

  • Utilized MC-29 virus-induced chicken hepatoma model.
  • Employed rodent, fish, and monkey models for chemical hepatocarcinogenesis.

Related Experiment Videos

  • Analyzed phenotypic enzyme alterations and oncogene/growth factor expression.

    • Main Results:

    • Experimentally induced hepatomas show phenotypic enzyme changes and altered oncogene/growth factor expression, mirroring human lesions.
    • Increased transforming growth factor alpha expression observed in both experimental and human liver tumors.
    • Transgenic mice with transforming growth factor alpha and c-myc genes exhibited increased tumor incidence.

    Conclusions:

    • Animal models are valuable for understanding liver tumor development and identifying biomarkers.
    • Fish hepatocarcinogenesis models are useful for assessing environmental pollutants' impact on liver health.
    • Comparative analysis of experimental models and human lesions enhances the study of premalignant and malignant liver diseases.