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Related Experiment Videos

Coeliac disease: always something to discover

A Várkonyi1, M Boda, E Endreffy

  • 1Dept. of Paediatrics, Albert Szent-Györgyi Medical University, Szeged, Hungary.

Scandinavian Journal of Gastroenterology. Supplement
|December 29, 1998
PubMed
Summary

Coeliac disease affects hair shaft zinc and prolactin levels, with gluten-free diets improving these markers. Genetic factors like DQB1*0201/2, DR3, and DR7 alleles are strongly associated with coeliac disease.

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Area of Science:

  • Gastroenterology
  • Genetics
  • Biochemistry

Background:

  • Coeliac disease is an autoimmune disorder triggered by gluten ingestion.
  • Long-term effects and diagnostic markers beyond intestinal biopsy are areas of ongoing research.
  • Understanding the systemic impact of coeliac disease is crucial for comprehensive patient management.

Purpose of the Study:

  • To investigate the long-term effects of coeliac disease on hair shaft characteristics, zinc levels, and prolactin.
  • To assess the impact of gluten-free diets on these parameters.
  • To identify genetic associations with coeliac disease.

Main Methods:

  • Scanning electron microscopy for hair shaft analysis.
  • Proton-induced X-ray emission for elemental analysis (zinc).

Related Experiment Videos

  • Hormonal assays for prolactin levels and biochemical analysis of erythrocyte glutathione.

    • Main Results:

    • Reduced hair diameter and increased cuticular erosion in untreated coeliac patients, normalizing with gluten-free diets.
    • Significantly lower hair shaft zinc in active coeliac disease, normalizing after one year of diet.
    • Hyperprolactinaemia observed in children with active coeliac disease, normalizing with diet.
    • Altered erythrocyte glutathione and glutathione disulfide levels in coeliac children compared to controls and iron-deficient children.
    • Strong genetic association with DQB1*0201/2, DR3, and DR7 alleles.

    Conclusions:

    • Coeliac disease significantly impacts hair shaft integrity, zinc metabolism, and prolactin levels.
    • Gluten-free diets demonstrate a positive therapeutic effect on these coeliac disease-related markers.
    • Specific human leukocyte antigen (HLA) alleles are strongly associated with coeliac disease susceptibility.