Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple line source array for SPECT transmission scans: simulation, phantom and patient studies

A Celler1, A Sitek, E Stoub

  • 1Vancouver Hospital and Health Sciences Centre, and University of British Columbia, Canada.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|December 29, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Digit ratio (2D:4D) in women and men with lung cancer.

Scientific reports·2020
Same author

Selected genes polymorphisms and the risk of non-syndromic striae. A case-control study in the Polish population.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Analysis of radioactive waste generated during the cyclotron production of <sup>99m</sup>Tc.

Physics in medicine and biology·2019
Same author

Association of five SNPs with human hair colour in the Polish population.

Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen·2017
Same author

Parental smoking during pregnancy shortens offspring's legs.

Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen·2016
Same author

Imaging study of using radiopharmaceuticals labeled with cyclotron-produced <sup>99m</sup>Tc.

Physics in medicine and biology·2016
Same journal

Overall Survival with [<sup>177</sup>Lu]Lu-PSMA-617 Versus [<sup>177</sup>Lu]Lu-PSMA I&T: A Propensity Score-Matched Real-World Analysis.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same journal

Toward a Biopsy-Free Diagnosis of Prostate Cancer: Potential of Combined <sup>18</sup>F-Flotufolastat PSMA PET and mpMRI.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same journal

PSMA PET/CT-Targeted Biopsy in Men with Negative or Equivocal Multiparametric MRI and Exploratory Dynamic Total-Body PET: The FUPERMAN Study.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same journal

Erratum.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same journal

Live from 2026 SNMMI Annual Meeting in Los Angeles!

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same journal

CAR T-Cell Therapy for Cancer: Updates and Challenges for Response Assessment.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
See all related articles

A novel multiple line source array (MLA) transmission system accurately generates attenuation maps for SPECT imaging. This method enables precise, object-specific attenuation correction, improving image quality in quantitative SPECT studies.

Area of Science:

  • Nuclear medicine
  • Medical imaging physics

Background:

  • Accurate attenuation and scatter corrections are crucial for quantitative SPECT studies.
  • Attenuation maps, representing object density, are required for these corrections.
  • Simultaneous emission/transmission scans offer a method for obtaining these maps.

Purpose of the Study:

  • To develop and evaluate a new multiple line source array (MLA) method for transmission scans.
  • To assess the performance of the MLA system in generating accurate attenuation maps for SPECT.
  • To demonstrate the utility of MLA-derived attenuation maps for object-specific correction of emission images.

Main Methods:

  • A multiple line source array (MLA) was designed for transmission scans, with higher activity in central lines.
  • Computer simulations and experimental data were used to investigate MLA performance.

Related Experiment Videos

  • Transmission-only and simultaneous emission/transmission studies were conducted using phantoms and human subjects.
  • Attenuation maps were generated and applied to reconstruct attenuation-corrected emission images.

    • Main Results:

    • MLA-generated attenuation maps showed no artifacts and were qualitatively and quantitatively accurate.
    • The agreement between measured and true mu coefficients for water was within 4% in phantom studies.
    • Attenuation-corrected emission images of phantoms accurately reconstructed cardiac activity.
    • Patient data showed significant qualitative improvement with MLA-based attenuation correction.

    Conclusions:

    • The MLA transmission source is effective for simultaneous emission/transmission imaging.
    • Accurate attenuation maps can be generated using the MLA system.
    • Object-specific attenuation correction of emission images is feasible and improves quantitative SPECT.