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[Effects of smoking on oxygen free radicals and fibrinolytic system]
1Department of Cardiac Medicine, Xiangya Hospital, Hunan Medical University, Changsha.
Unlabelled:
The effects of smoking on SOD, MDA, t-PA, PAI-1 were studied in 20 healthy men (10 smokers and 10 nonsmokers).
Results:
SOD decreased and MDA increased significantly in smokers. After acute smoking, SOD decreased and MDA increased significantly in all the subjects, t-PA and PAI-1 activities were increased immediately after acute smoking. There was a significant positive relationship between increased t-PA and SOD, whereas a significant negative relationship exists between increased t-PA and MDA.
Conclusion:
Smoking increases oxygen free radicals. The release of t-PA is decreased in smokers, that might be resulted from the increases of oxygen free radicals.