[A histopathological study on Hunan aqueous drainage implantation in rabbit's eye]

Thirty eyes with 15 healthy white New Zealand rabbits subgrouped into two groups: right eye as an experimental group which was implanted Hunan aqueous drainage (HAD) and left eye served as self-control group in which a silicone band 7 mm in width and 7 to 10 mm in length was placed equatorially around the globe. Within 1 to 12 weeks postoperatively, we examined the anterior segment of the globe by the slit lamp microscopy (SLM) and made histopathological observation under light microscope after sacrifice and enucleation of eyeballs in five batches. SLM examination showed that 8 out of 15 eyes in experimental group showed mild or moderate ocular reaction which subsided within 2 to 14 days postoperatively. Histopathological observation revealed no obvious pathological lesions in the uveal tract tissues in the most globes. No foreign body macrophages were found. It indicates that HAD implant is nontoxic and nonallergenic, so it is adaptable for rabbit ocular tissue. The HAD implant can be used in human eyes, too.