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Updated: Aug 12, 2026

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
[Complications of plateletpheresis procedures]
J M García Gala1, P Rodríguez-Vicente, E Martínez Revuelta
1Banco de Sangre, Servicio Hematología y Hemoterapia, Hospital Central de Asturias, Oviedo, España. jgarcig@nexo.es
Thrombopheresis can cause adverse effects in 25.3% of donors, primarily mild paresthesia. Males over 70kg are less likely to experience complications, and calcium supplements do not prevent adverse reactions during thrombopheresis.
Area of Science:
- Hematology
- Transfusion Medicine
Context:
- Thrombopheresis procedures are increasingly common.
- Understanding donor risk factors for adverse effects is crucial for patient safety.
- Previous guidelines for donor selection were limited.
Purpose:
- To analyze thrombopheresis procedures performed between 1986-1997.
- To identify predictors of adverse effects in thrombopheresis donors.
- To establish guidelines for selecting low-risk donors.
Summary:
- 1,024 thrombopheresis procedures were analyzed.
- Adverse effects occurred in 25.3% of procedures, mostly mild.
- Female sex and low body weight were associated with increased adverse effects.
Impact:
- Identified key demographic factors (sex, weight) for predicting adverse events.
- Findings can inform donor selection protocols to minimize complications.
- Demonstrated that prophylactic calcium administration is ineffective in preventing adverse reactions.
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