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A furan derivative from Cornus officinalis

D K Kim1, J H Kwak

  • 1College of Pharmacy, Woosuk University, Samrye, Korea.

Archives of Pharmacal Research
|December 30, 1998
PubMed
Summary

A novel furan derivative, dimethyltetrahydrofuran cis-2,5-dicarboxylate, was discovered in Cornus officinalis fruits. This marks its first isolation from a natural source, with its structure confirmed using NMR spectroscopy.

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Area of Science:

  • Natural Product Chemistry
  • Organic Chemistry
  • Phytochemistry

Background:

  • Cornus officinalis (Cornelian cherry) is a traditional medicinal plant.
  • Furan derivatives are known for diverse biological activities.
  • Exploration of secondary metabolites in Cornus officinalis is ongoing.

Purpose of the Study:

  • To isolate and identify novel compounds from Cornus officinalis fruits.
  • To characterize the chemical structure of newly discovered natural products.
  • To report the first natural occurrence of dimethyltetrahydrofuran cis-2,5-dicarboxylate.

Main Methods:

  • Extraction of compounds from Cornus officinalis fruits.
  • Purification using chromatographic techniques.
  • Structure elucidation via Nuclear Magnetic Resonance (NMR) spectroscopy.

Main Results:

  • Isolation of dimethyltetrahydrofuran cis-2,5-dicarboxylate.
  • Confirmation of the cis-2,5-dicarboxylate configuration.
  • Identification as a novel natural product.

Conclusions:

  • Dimethyltetrahydrofuran cis-2,5-dicarboxylate is a naturally occurring compound found in Cornus officinalis.
  • This discovery expands the known chemical diversity of Cornus officinalis.
  • NMR spectroscopy is a powerful tool for natural product structure determination.

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