Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preventing end-stage renal disease

C E Mogensen1

  • 1Department of Diabetes and Endocrinology, Aarhus Kommunehospital, Denmark.

Diabetic Medicine : a Journal of the British Diabetic Association
|December 30, 1998
PubMed
Summary

Early intervention for diabetes complications is key. Optimal glycaemic control and angiotensin-converting enzyme (ACE) inhibitors prevent organ damage and reduce mortality in diabetic patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lowering Albuminuria-Does It Lower the Cardiovascular Risk?: Reduction in Albuminuria Translates to Reduction in Cardiovascular Events in Hypertensive Patients: Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 45: 198-202, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Reducing Microalbuminuria-Does It Lower Cardiovascular Risk?: Reduction in Albuminuria Translates to Reduction in Cardiovascular Events in Hypertensive Patients: Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 45: 198-202, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Ambulatory pulse pressure, decreased nocturnal blood pressure reduction and progression of nephropathy in type 2 diabetic patients.

Diabetologia·2009
Same author

Reduction in albuminuria translates to reduction in cardiovascular events in hypertensive patients with left ventricular hypertrophy and diabetes.

Journal of nephrology·2008
Same author

Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial.

Lancet (London, England)·2007
Same author

Endothelial dysfunction, ambulatory pulse pressure and albuminuria are associated in Type 2 diabetic subjects.

Diabetic medicine : a journal of the British Diabetic Association·2007

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiology

Background:

  • Diabetes mellitus (Type 1 and Type 2) significantly increases mortality risk due to renal disease, cardiovascular disease, and blindness.
  • Diabetic complications often occur concurrently, highlighting the need for early intervention to prevent organ damage.
  • Microalbuminuria serves as a critical early indicator of advanced renal disease, retinopathy, and mortality in diabetic patients.

Purpose of the Study:

  • To review evidence on preventing and managing diabetic complications, focusing on microalbuminuria and overt nephropathy.
  • To assess the impact of glycaemic control and specific pharmacotherapies on the progression of diabetic kidney disease and cardiovascular outcomes.

Main Methods:

  • Review of clinical trials and long-term studies in Type 1 and Type 2 diabetic patients.
  • Analysis of data on microalbuminuria, proteinuria, glomerular filtration rate (GFR), and mortality.
  • Evaluation of the effects of optimal glycaemic control, angiotensin-converting enzyme (ACE) inhibitors, and other antihypertensive agents.

Main Results:

  • Optimal glycaemic control reduces the risk of microalbuminuria and helps preserve glomerular filtration rate (GFR).
  • Angiotensin-converting enzyme (ACE) inhibitors are effective in reducing microalbuminuria and preventing GFR decline in patients with microalbuminuria.
  • Long-term ACE inhibitor use can postpone end-stage renal disease mortality and cardiovascular mortality in diabetic patients.

Conclusions:

  • Early screening for microalbuminuria, achieving optimal glycaemic control, and prompt treatment with ACE inhibitors are crucial for preventing diabetic complications, particularly nephropathy.
  • Antihypertensive therapy, including ACE inhibitors, plays a vital role in managing diabetic complications and improving cardiovascular outcomes.
  • While calcium channel blockers have some controversy, the primary focus should be on glycaemic control and ACE inhibitors for preventing diabetic nephropathy progression.

Related Experiment Videos