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Preventive therapy for tuberculosis in Western Australia

S C Pang1, R H Harrison, J Brearley

  • 1Tuberculosis Control Programme, Perth Chest Clinic, Western Australia, Australia.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|December 30, 1998
PubMed
Summary

Preventive therapy for tuberculosis (TB) in Western Australia showed good adherence, with 90% completing treatment. However, 24% of individuals on isoniazid monotherapy experienced non-adherence, often linked to adverse drug effects.

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Corrigendum to "Re: does reducing radiation levels for procedures affect image quality and radiation to proceduralists? A double-blinded randomized study of two protocols" [76 (2) e1-e10].

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Area of Science:

  • Public Health
  • Infectious Diseases
  • Epidemiology

Background:

  • Tuberculosis (TB) remains a global health concern requiring effective preventive strategies.
  • Indirectly supervised treatment is a model for delivering preventive therapy in resource-limited settings.
  • Assessing the real-world application of TB preventive therapy is crucial for program improvement.

Purpose of the Study:

  • To evaluate the baseline information, applicability, and efficacy of indirectly supervised TB preventive therapy.
  • To identify factors influencing treatment adherence and outcomes in a real-world setting.

Main Methods:

  • Retrospective analysis of records from the State Tuberculosis Control Programme in Western Australia (1993-1996).
  • Inclusion of individuals prescribed TB preventive therapy following screening (migrant surveillance, contact tracing, surveys).

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  • Descriptive statistics were used to analyze adherence, adverse events, and treatment completion.

    • Main Results:

    • 411 individuals received preventive therapy, primarily six-month isoniazid monotherapy (HMT).
    • Treatment non-adherence was observed in 24% of HMT recipients, with 10% taking medication for less than five months.
    • Adverse drug effects were reported in 9% and contributed to non-adherence in 23 individuals.

    Conclusions:

    • TB preventive therapy in Western Australia aligned with established guidelines.
    • Despite challenges, 90% of individuals achieved adequate therapy completion under indirect supervision.
    • Adverse drug effects were a significant factor contributing to treatment non-adherence.